Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?
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منابع مشابه
Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?
Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal (n = 66) and ...
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The p53 tumor suppressor gene frequently is mutated in many forms of human carcinomas. A common polymorphism occurs at codon 72 of exon 4, with two alleles encoding either arginine (CGC) or proline (CCC). This p53 polymorphism reportedly is associated with lung cancer susceptibility. However, not all investigations have been consistent, and this hypothesized association remains controversial. W...
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ژورنال
عنوان ژورنال: Medical Oncology
سال: 2017
ISSN: 1357-0560,1559-131X
DOI: 10.1007/s12032-017-0893-6